Filters
Sensor Target Type Specificitysort ascending Sensor Name Sensor Type Analysis Technique IV Properties Organism Binding Protein Fluorophore PIs
Metabolites

cGMP

cGES sensors

FRET-based biosensors confocal flourescence microscopy HEK-293 cells GAF-B domain of PDE2A and GAF-A domain of PDE5A eCFP, eYFP Lohse MJ
Metabolites

cGMP

cGi sensors

FRET-based biosensors spectroscopy, fluorescence microscopy cGMP concentration 1-2 µM HEK293 cells cGMP-binding sites cNMP-BD (cGKI) or GAF (PDE5) eCFP, eYFP Koesling D
Metabolites

cGMP

Cygnus

FRET-based biosensors FLIM, confocal fluorescence microscopy, spectroscopy pH-sensitive PC12 cells, HEK 293T cells, HeLa cells cGMP binding from PDE5 mTagBFP, sREACh(dark) Oka K
Regulated Proteolysis

Cell cycle progression

Fucci

Single FP-based extrinsic biosensors COS-7 cells, HeLa Cells RFP, GFP Miyawaki A
Ions

Cd2+

Cd-FRET-2

FRET-based biosensors Merkx M
Metabolites

cAMP

FP-PKARII/FP-PKAcat

FRET-based biosensors eBFP and GFP or CFP and YFP Pozzan T, Pozzan T
Metabolites

cAMP

CFP–Epac–YFP

FRET-based biosensors fluorescence microscopy highly sensitive cAMP indicator, Kd of 2.3 µM human A431 cells, Rat-1 and NIH3T3 fibroblasts, mouse GE11 epithelial cells, mouse N1E-115 neuroblastoma, human MCF7 breast carcinoma cells cAMP binding CFP, YFP Jalink K
Metabolites

cAMP

ICUEs

FRET-based biosensors eCFP, Citrine Zhang J, Zhang J, Lefkowitz RJ
Metabolites

cAMP

Epac-camps

FRET-based biosensors spectroscopy, fluorescence microscopy sensitive cAMP indicators Sf9 cells, CHO-A2B, TsA201, HEK293, COS-7 cells cAMP binding eCFP, eYFP Lohse MJ
Metabolites

cAMP

PKA-camps

FRET-based biosensors spectroscopy, fluorescence microscopy sensitive cAMP indicators Sf9 cells, CHO-A2B, TsA201, HEK293, COS-7 cells cAMP binding eCFP, eYFP Lohse MJ
Metabolites

cAMP

HCN2-camps

FRET-based biosensors confocal flourescence microscopy, FRAP cAMP-sensitive HEK 293a cells, mouse heart single cAMP binding of HCN2 channel- a helices covering cAMP binding site eCFP, eYFP Engelhardt S
Metabolites

cAMP

(T)Epac(VV)

FRET-based biosensors FLIM, confocal fluorescence microscopy cAMP indicators Hek293 cells, N1E-115, human HeLa cells (ccl-2) cAMP binding mTurquise (mECFPD-Epac(CD, and DEP)-cp173Venus-Venus Jalink K
Protein Activation and Conformation

CaMKII conformation

CamuiαamCYCaMIIα

FRET-based biosensors two-photon fluorescence microscopy HeLa cells YFP(Venus) , CFP (S175G) Schultz C, Hayashi Y
Ions

Ca2+

Pericams

Single FP-based extrinsic biosensors Tsien RY, Miyawaki A, Campbell RE
Ions

Ca2+

GCaMPs

Single FP-based extrinsic biosensors Tsien RY, Imoto K, Kotlikoff MI, Looger LL, Campbell RE, Harvey BK
Ions

Ca2+

Case12/16

Single FP-based extrinsic biosensors Tsien RY, Chudakov DM, Campbell RE
Ions

Ca2+

Camgaroos

Single FP-based extrinsic biosensors Tsien RY, Campbell RE
Ions

Ca2+

B-GECO

Single FP-based extrinsic biosensors Tsien RY, Campbell RE
Ions

Ca2+

G-GECO

Single FP-based extrinsic biosensors Tsien RY, Campbell RE
Ions

Ca2+

jRCaMP1a, b

Single FP-based extrinsic biosensors Cultured neurons mRuby Kim DS
Ions

Ca2+

R-GECO

Single FP-based extrinsic biosensors Tsien RY, Campbell RE
Ions

Ca2+

jRGECO1a

Single FP-based extrinsic biosensors Cultured neurons mApple Kim DS
Ions

Ca2+

Cameleons

FRET-based biosensors Tsien RY, Miyawaki A, Tsien RY, Persechini A, Ikura M
Ions

Ca2+

FIP-CBSMTN-XL

FRET-based biosensors Miyawaki A, Persechini A,, Ikura M
Ions

Ca2+

TN-XXL

FRET-based biosensors Griesbeck O, Miyawaki A, Persechini A, Ikura M

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