Filters
Sensor Target Type Specificity Sensor Name Sensor Type Analysis Technique IV Propertiessort descending Organism Binding Protein Fluorophore PIs
Metabolites

PtdIns(4,5)P2

GFP-Cytohesin-1

Translocation-based biosensors Czech MP
Protein Activation and Conformation

Insulin receptor activation

Sinphos

Single FP-based extrinsic biosensors CHO-IR cells, CHO-K1 cells CFP(cpFP), GFP(cpFP) Umezawa Y
Ions

pH

pHluorins

Single FP-based intrinsic biosensors Rothman JE
Metabolites

Phosphatidic acid

Pii

FRET-based biosensors Kiyokawa E
Metabolites

PtdIns(4,5)P2

GFP-PHOSH2

Translocation-based biosensors confocal microscopy HeLa cells, yeast cells eGFP Lemmon MA
Protein Activation and Conformation

M(1) muscarinic receptor (M(1)R) activation

M1R-YFP-CFP

FRET-based biosensors fluorescence microscopy tsA-201 cells eCFP, eYFP Hille B
Ions

pH

GFpH

Single FP-based intrinsic biosensors Miyazaki S
Metabolites

Phosphatidylserine

GFP-Lact-C2

Translocation-based biosensors Grinstein S
Kinase Activity

Extracellular signal-regulated kinase (ERK)

Miu2

FRET-based biosensors HeLa cells CFP, YFP Matsuda M
Metabolites

PtdIns(4,5)P2

PHOSBP

Translocation-based biosensors confocal microscopy COS-7 cells GFP, mRFP Balla T, Munro S
Metabolites

cAMP

FP-PKARII/FP-PKAcat

FRET-based biosensors eBFP and GFP or CFP and YFP Pozzan T, Pozzan T
Protein Activation and Conformation

MAP kinase-activated protein kinase 2 conformation

GMB

FRET-based biosensors HEK293 cells, Swiss 3T3 cells eCFP, eBFP Gaestel M
Ions

pH

YFpH

Single FP-based intrinsic biosensors Miyazaki S
Metabolites

PtdIns(3,4,5)P3

GFP-ARNO

Translocation-based biosensors Czech MP
Kinase Activity

Glucokinase

mCerulean-GCK-mVenus

FRET-based biosensors confocal flourescence microscopy BTC3 cells YFP Rizzo MA
Metabolites

PtdIns(4,5)P2

GFP-PHFAPP

Translocation-based biosensors confocal microscopy HeLa cells, yeast cells eGFP Lemmon MA
Enzyme Activity (Non-Kinase)

histone H4 lysine acetylation

Histac (K5, K7)

FRET-based biosensors CFP, YFP(venus) Yoshida M
Protein Activation and Conformation

PKB conformation

GFP-PKB-RFP

FRET-based biosensors NIH 3T3 eGFP , RFP Larijani B
Ions

pH

mtAlpHi

Single FP-based intrinsic biosensors Pozzan T
Metabolites

PtdIns(3,4,5)P3

GFP-PHGRP1

Translocation-based biosensors confocal microscopy PC12 cells GFP Cullen PJ, Czech MP
Kinase Activity

Histone H3 phosphorylation

H3 phosphorylation reporter

FRET-based biosensors inverted epiflourescence microscopy HeLa cells CFP, YFP Ting AY
Metabolites

PtdIns(4,5)P2

CAY

FRET-based biosensors Swiss 3T3 fibroblasts Allen PG
Enzyme Activity (Non-Kinase)

histone H4 lysine acetylation

Histac-K12 (K12)

FRET-based biosensors confocal microscopy COS7 cells CFP, YFP(venus) Yoshida M
Metabolites

cAMP

ICUEs

FRET-based biosensors eCFP, Citrine Zhang J, Zhang J, Lefkowitz RJ
Protein Activation and Conformation

Rho family GTPase activation

Raichu-Rap1

FRET-based biosensors Matsuda M, Matsuda M

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